POLYCAPROLACTONE FIBER-BASED BOVINE DENDRITIC CELL DEVELOPMENT AND THREE- DIMENSIONAL CULTURE IN VITRO

Two-dimensional (2D) cell culture systems are normally used for in vitro experiments. These have some drawbacks which affect results of experiments because cultured cells different morphology and physiological properties comparing to vivo models. Therefore, there current technique develop three-dimensional (3D) closer the environment real tissues. In our study, we polycaprolactone fiber scaffold bovine monocytes dendritic (DCs) from those cells. Cultured nanofiber differentiated DCs. The DCs showed a 3D structure scaffold. suggest that this method is suitable development manner three-dimension. perspective has advantages compare conventional 2D systems.